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AUTOIMMUNE DISEASE

Updated: Jul 22

Over 100 different diseases are caused by a compromised immune system.

Autoimmune Diseases


Top 10 Autoimmune Diseases


  • Rheumatoid Arthritis - The immune system produces antibodies that attach to the linings of joints. Immune system cells then attack the joints, causing inflammation, swelling, and pain and gradually causes permanent joint damage.


  • Systemic Lupus Erythematosus (Lupus) - People with lupus develop autoimmune antibodies that can attach to tissues throughout the body. The joints, lungs, blood cells, nerves, and kidneys are commonly affected in lupus. Treatment often requires daily oral prednisone, a steroid that reduces immune system function.


  • Inflammatory Bowel Disease (IBD) - The immune system attacks the lining of the intestines, causing episodes of diarrhea, rectal bleeding, urgent bowel movements, abdominal pain, fever, and weight loss. Ulcerative colitis and Crohn's disease are the two major forms of IBD. Oral and injected immune-suppressing medicines can treat IBD.


  • Crohn's Disease - Affects your digestive system and is characterized by symptoms such as diarrhea, intense abdominal cramping, and severe weight loss. The Crohn's and Colitis Foundation of America suggest that around 1.6 million Americans are diagnosed with this common autoimmune disease. Although there is no clear link as to why some people develop this condition, a controlled diet, medication, and even surgery can be necessary.


  • Multiple Sclerosis (MS) - The immune system attacks nerve cells, causing symptoms that can include pain, blindness, weakness, poor coordination, and muscle spasms. Various medicines that suppress the immune system can be used to treat multiple sclerosis.

  • Type 1 Diabetes Mellitus - Immune system antibodies attack and destroy insulin-producing cells in the pancreas. By young adulthood, people with type 1 diabetes require insulin injections to survive.


  • Guillain-Barre Syndrome - The immune system attacks the nerves controlling muscles in the legs and sometimes the arms and upper body. Weakness results, which can sometimes be severe. Filtering the blood with a procedure called plasmapheresis is the main treatment for Guillain-Barre syndrome.


  • Chronic Inflammatory Demyelinating Polyneuropathy - Similar to Guillian-Barre, the immune system also attacks the nerves in CIDP, but symptoms last much longer. About 30% of patients can become confined to a wheelchair if not diagnosed and treated early. Treatment for CIDP and GBS are essentially the same.


  • Psoriasis - In psoriasis, overactive immune system blood cells called T-cells collect in the skin. The immune system activity stimulates skin cells to reproduce rapidly, producing silvery, scaly plaques on the skin.


  • Graves' Disease - The immune system produces antibodies that stimulate the thyroid gland to release excess amounts of thyroid hormone into the blood (hyperthyroidism). Symptoms of Graves' disease can include bulging eyes as well as weight loss, nervousness, irritability, rapid heart rate, weakness, and brittle hair. Destruction or removal of the thyroid gland, using medicines or surgery, is usually required to treat Graves' disease.


  • Hashimoto's Thyroiditis - Antibodies produced by the immune system attack the thyroid gland, slowly destroying the cells that produce thyroid hormone. Low levels of thyroid hormone develop (hypothyroidism), usually over months to years. Symptoms include fatigue, constipation, weight gain, depression, dry skin and sensitivity to the cold.



Full List of Auto-Immune Diseases

Achalasia

Addison’s disease

Adult Still's disease

Agammaglobulinemia

Alopecia areata

Amyloidosis

Ankylosing spondylitis

Anti-GBM/Anti-TBM nephritis

Antiphospholipid syndrome

Autoimmune angioedema

Autoimmune dysautonomia

Autoimmune encephalomyelitis

Autoimmune hepatitis

Autoimmune inner ear disease (AIED)

Autoimmune myocarditis

Autoimmune oophoritis

Autoimmune orchitis

Autoimmune pancreatitis

Autoimmune retinopathy

Autoimmune urticaria

Axonal & neuronal neuropathy (AMAN)

Baló disease

Behcet’s disease

Benign mucosal pemphigoid

Bullous pemphigoid

Castleman disease (CD)

Celiac disease

Chagas disease

Chronic inflammatory demyelinating polyneuropathy (CIDP)

Chronic recurrent multifocal osteomyelitis (CRMO)

Churg-Strauss Syndrome (CSS) or Eosinophilic Granulomatosis (EGPA)

Cicatricial pemphigoid

Cogan’s syndrome

Cold agglutinin disease

Congenital heart block

Coxsackie myocarditis

CREST syndrome

Crohn’s disease

Dermatitis herpetiformis

Dermatomyositis

Devic’s disease (neuromyelitis optica)

Discoid lupus

Dressler’s syndrome

Endometriosis

Eosinophilic esophagitis (EoE)

Eosinophilic fasciitis

Erythema nodosum

Essential mixed cryoglobulinemia

Evans syndrome

Fibromyalgia

Fibrosing alveolitis

Giant cell arteritis (temporal arteritis)

Giant cell myocarditis

Glomerulonephritis

Goodpasture’s syndrome

Granulomatosis with Polyangiitis

Graves’ disease

Guillain-Barre syndrome

Hashimoto’s thyroiditis

Hemolytic anemia

Henoch-Schonlein purpura (HSP)

Herpes gestationis or pemphigoid gestationis (PG)

Hidradenitis Suppurativa (HS) (Acne Inversa)

Hypgammalglobulinemia

IgA Nephropathy

IgG4-related sclerosing disease

Immune thrombocytopenic purpura (ITP)

Inclusion body myositis (IBM)

Interstitial cystitis (IC)

Juvenile arthritis

Juvenile diabetes (Type 1 diabetes)

Juvenile myositis (JM)

Kawasaki disease

Lambert-Eaton syndrome

Leukocytoclastic vasculitis

Lichen planus

Lichen sclerosus

Ligneous conjunctivitis

Linear IgA disease (LAD)

Lupus

Lyme disease chronic

Meniere’s disease

Microscopic polyangiitis (MPA)

Mixed connective tissue disease (MCTD)

Mooren’s ulcer

Mucha-Habermann disease

Multifocal Motor Neuropathy (MMN) or MMNCB

Multiple sclerosis

Myasthenia gravis

Myositis

Narcolepsy

Neonatal Lupus

Neuromyelitis optica

Neutropenia

Ocular cicatricial pemphigoid

Optic neuritis

Palindromic rheumatism (PR)

PANDAS

Paraneoplastic cerebellar degeneration (PCD)

Paroxysmal nocturnal hemoglobinuria (PNH)

Parry Romberg syndrome

Pars planitis (peripheral uveitis)

Parsonage-Turner syndrome

Pemphigus

Peripheral neuropathy

Perivenous encephalomyelitis

Pernicious anemia (PA)

POEMS syndrome

Polyarteritis nodosa

Polyglandular syndromes type I, II, III

Polymyalgia rheumatica

Polymyositis

Postmyocardial infarction syndrome

Postpericardiotomy syndrome

Primary biliary cirrhosis

Primary sclerosing cholangitis

Progesterone dermatitis

Psoriasis

Psoriatic arthritis

Pure red cell aplasia (PRCA)

Pyoderma gangrenosum

Raynaud’s phenomenon

Reactive Arthritis

Reflex sympathetic dystrophy

Relapsing polychondritis

Restless legs syndrome (RLS)

Retroperitoneal fibrosis

Rheumatic fever

Rheumatoid arthritis

Sarcoidosis

Schmidt syndrome

Scleritis

Scleroderma

Sjögren’s syndrome

Sperm & testicular autoimmunity

Stiff person syndrome (SPS)

Subacute bacterial endocarditis (SBE)

Susac’s syndrome

Sympathetic ophthalmia (SO)

Takayasu’s arteritis

Temporal arteritis/Giant cell arteritis

Thrombocytopenic purpura (TTP)

Tolosa-Hunt syndrome (THS)

Transverse myelitis

Type 1 diabetes

Ulcerative colitis (UC)

Undifferentiated connective tissue disease (UCTD)

Uveitis

Vasculitis

Vitiligo

Vogt-Koyanagi-Harada Disease


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